|
KMID : 1007520000090040204
|
|
Food Science and Biotechnology
2000 Volume.9 No. 4 p.204 ~ p.208
|
|
|
Inhibition of Human Low Density Lipoprotein Oxidation by Extracts from Rhus verniciflua Strokes
|
|
Ryu Beung-Ho
|
|
|
Abstract
|
|
|
|
Oxidative modification of low density lipoprotein (LDL) is believed to play a crucial role in atherogenesis. The antioxidative activity of polyphenol compounds typically present in Rhus verniciflua Strokes was investigated in vitro using a human LDL oxidation assay. LDL was incubated with increasing concentrations of extracts of Rhus verniciflua Strokes, and LDL oxidation was initiated by adding CuS0₄to the media. Substances in leaf extracts of Rhus verniciflua Strokes are capable of inhibiting the initiation and the propagation of LDL oxidation. They inhibit LDL oxidation, monitored by thiobarbituric acid-reactive substances, as well as modification as shown through direct measurement of electrophoretic mobility and fluorescence. Inhibition is a dose dependent effect that becomes readily apparent at concentration of extracts as low as 50 ㎍/mL. Inhibition is almost complete at 60.5 ㎍/mL. Stem extracts showed similar effects with less potency. Leaf extracts of Rhus verniciflua Strokes had more potent antioxidative activity than both ascorbic acid and dl-α-tocopherol.
|
|
|
KEYWORD
|
|
|
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
 
|